Microfluidics Research Engineer

Job description: Chronic and serious cases of diabetes type 1 are currently treated by islet grafts. These transplants have a miraculous effect on the quality of life of patients. However, the efficacy and survival rate of the implant diminishes over the years. At CEA-Leti we are starting a long-term ambitious project in collaboration with the Grenoble Alpes University Hospital to develop biological twin models following patients’ transplants. We aim to provide clinicians with insights into the patient’s immune response allowing them to better make clinical decisions. We are currently seeking a motivated and talented researcher to join our team. Our objectives are to design, prototype and validate a microfluidic platform with monitoring and multisensing approaches enabling the study of interactions between transplanted islets and immune cells isolated from the islet recipient, as a predictive tool for clinicians of islet transplant rejection and immune relapse and/or loss of efficacy of immunosuppressive treatment. You will contribute to the development of a modular microfluidic platform dedicated to organ-on-chip applications. The position has a strong accent on microfluidic experimentation in order to ensure robustness and reliability of the system. In close collaboration with experts in biology, manufacturing and sensor technologies, you will be responsible for the microfluidic aspects of the biological experiments. The position requires you to be pragmatic and hands-on in your role as a facilitator. Your activities will include: microfluidic experimentation with or without biological components characterization of microfluidic devices setting up test environments using and improving software for control and acquisition analysis and interpretation of results

Institute description: Within the Department of Technologies for Health Innovation, the multidisciplinary team of the Microfluidic Systems and Bioengineering Laboratory designs and builds microfluidic systems for applications in biology and healthcare.

Your profile: De formation ingénieur (MSc) et/ou docteur (PhD), vous avez une forte expertise en développement microfluidique. Des connaissances en techniques de fabrication sont un plus ainsi qu’une expérience dans la thématique des organes sur puce. Attiré(e) par un environnement pluridisciplinaire et l’innovation technologique, vous faites preuve d’engagement et de culture du résultat dans la réalisation de vos projets. Motivé(e) par le travail expérimental (paillasse), vous savez travailler en équipe avec des interlocuteurs aux profils très variés. Rigueur, dynamisme et sens de l'organisation seront particulièrement appréciés. La maîtrise de l’anglais est nécessaire. Conformément aux engagements pris par le CEA en faveur de l'intégration des personnes handicapées, cet emploi est ouvert à toutes et à tous. Le CEA propose des aménagements et/ou des possibilités d'organisation pour l’inclusion des travailleurs handicapés

Languages: English Intermediate