Sepsis is among the main cause of death across the world, and is caused by severe bacterial infection but can also originate from viruses, fungi or even parasites. In order to drastically increase survival rates, a rapid diagnostic and appropriate treatment is of paramount importance. The commercially available tools for nucleic acid detection by qPCR...

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The culture of adherent cells on microcarriers (MCs) is a promising approach for various bioproduction applications, such as drug manufacturing and delivery, regenerative medicine, and tracking of cellular differentiation. However, the analysis of single cell morphology and behavior without affecting the substrate integrity remains a major challenge. Lens-free holographic imaging is emerging as a promising...

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Brain-computer interfaces (BCIs) make it possible to restore lost functions by allowing individuals to control external devices through the modulation of their brain activity. The CEA has developed a BCI technology based on the WIMAGINE implant, which records brain activity using electrocorticography (ECoG), along with algorithms for decoding motor intentions. This technology was initially tested...

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In most parasitic cycles, the free phase passes through an egg stage, which is released by the host into the environment via a complex faecal matrix, which has highly variable and often low egg concentrations. The classical detection method relies on microscopic observation of these eggs, which implies a tedious and time-consuming preparation of the...

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Infertility is a growing problem in all developed countries. The standard methods for the diagnostic of male infertility examine the concentration, motility and morphological anomalies of individual sperm cells. However, one in five male infertility cases remain unexplained with the standard diagnostic tools. In this thesis, we will explore the possibility to determine the male...

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