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phD
New rapid diagnostic tool for sepsis: microfluidic biochip for multi-target detection by isothermal amplification
Sepsis is among the main cause of death across the world, and is caused by severe bacterial infection but can also originate from viruses, fungi or even parasites. In order to drastically increase survival rates, a rapid diagnostic and appropriate treatment is of paramount importance. The commercially available tools for nucleic acid detection by qPCR...
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phD
On-line monitoring of bioproduction processes using 3D holographic imaging
The culture of adherent cells on microcarriers (MCs) is a promising approach for various bioproduction applications, such as drug manufacturing and delivery, regenerative medicine, and tracking of cellular differentiation. However, the analysis of single cell morphology and behavior without affecting the substrate integrity remains a major challenge. Lens-free holographic imaging is emerging as a promising...
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phD
Characterization of motor recovery in stroke patients during a BCI-guided rehabilitation
Brain-computer interfaces (BCIs) make it possible to restore lost functions by allowing individuals to control external devices through the modulation of their brain activity. The CEA has developed a BCI technology based on the WIMAGINE implant, which records brain activity using electrocorticography (ECoG), along with algorithms for decoding motor intentions. This technology was initially tested...
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phD
Ultra-wide-field smart microscope for the detection of egg parasite (SCREENER)
In most parasitic cycles, the free phase passes through an egg stage, which is released by the host into the environment via a complex faecal matrix, which has highly variable and often low egg concentrations. The classical detection method relies on microscopic observation of these eggs, which implies a tedious and time-consuming preparation of the...
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phD
Development of a Multilayer Encapsulation System for the Production of Core-Shell Microcapsules Suitable for Organoid Growth
Every year, 20 million people worldwide are diagnosed with cancer, with 9.7 million succumbing to the disease (Kocarnik et al., 2021). Personalized treatment could significantly reduce the number of deaths. This thesis addresses this challenge by proposing the development of organoids derived from patient biopsies to optimize treatments. The bioproduction of encapsulated cells in biopolymers...
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phD
Sperm 3D - Male infertility diagnostic tool using holography for imaging and 3D tracking
Infertility is a growing problem in all developed countries. The standard methods for the diagnostic of male infertility examine the concentration, motility and morphological anomalies of individual sperm cells. However, one in five male infertility cases remain unexplained with the standard diagnostic tools. In this thesis, we will explore the possibility to determine the male...
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phD
Efficient Multimodal Vision Transformers for Embedded System
The proposed thesis focuses on the optimization of multimodal vision transformers (ViT) for panoptic object segmentation, exploring two main directions. The first is to develop a versatile fusion pipeline to integrate multimodal data (RGB, IR, depth, events, point clouds) by leveraging inter-modal alignment relationships. The second is to investigate an approach combining pruning and mixed-precision...
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