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PostDoc
Microfluidic biocatalysis
The overall objective of the project is to propose a new mode of biocatalytic production based on continuous flow and combining macro and micro-fluidics. The aim is to develop a biocatalysis process involving fluidic bioreactors capable of ensuring continuous biotransformation, thanks to immobilized enzymes or whole cell catalysts. This process will be optimized to improve...
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phD
Development and multiparametric monitoring of a microfluidic chip of the blood-brain barrier model
The blood-brain barrier (BBB) protects the brain by controlling exchanges between the blood and nervous tissue. However, current models struggle to accurately reproduce its complexity. This thesis aims at developing and evaluating a microfluidic chip of BBB model incorporating a real-time monitoring system that combines simultaneous optical and electrical measurements. The device will enable the...
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phD
Optical intradermal sensing via instrumented microneedles
Cortisol plays a central role in regulating the circadian cycle and in many essential physiological processes such as energy metabolism and immune response. Conventional monitoring of cortisol relies on single blood or saliva samples, which do not accurately reflect the temporal dynamics of its secretion. It is therefore necessary to develop innovative approaches that enable...
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phD
Fluctuations microscopy for functional imaging of organoids
Phase contrast microscopy and fluorescence microscopy are the two pillars of modern biological imaging. Phase contrast reveals the morphology of the sample, while fluorescent labeling provides specificity to the process of interest. In both cases, the image is the average value of the measured signal. In this thesis, we propose to focus not on the...
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phD
On-line monitoring of bioproduction processes using 3D holographic imaging
The culture of adherent is a promising approach for various bioproduction applications, such as drug manufacturing and delivery, regenerative medicine, and tracking of cellular differentiation. However, the analysis of single cell morphology and behavior without affecting the substrate integrity remains a major challenge. Lens-free holographic imaging is emerging as a promising solution for real-time, non-invasive...
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phD
Image sensor-based differential phase contrast imaging
Biopharmaceutical production is booming and consists of using cells to produce molecules of interest. To achieve this, monitoring the culture and the state of the cells is essential. Quantitative phase imaging by holography is a label-free optical method that has already demonstrated its ability to measure the concentration and viability of cultured cells. However, implementing...
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phD
Development of an integrated solid state nanopore analysis system
The identification of biological material (DNA, RNA, proteins,…) is generally done thanks to cumbersome lab equipment and/or rely on ultra-specific and proprietary sensitive reagents. We aim to develop a new platform based on the solid-state nanopore technology which could produce label-free results on field. One way to pierce a nanopore in an ultra-fine dielectric membrane...
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Permanent contract
Engineer-Researcher in analytical chemistry
Title: Integration of an analytical protocol for the characterization of nanoparticles Our technological development project aims to develop a new concept for characterizing lipid nanoparticles (LNPs) that carry biomolecules. More specifically, the goal is to verify the analytical performance of an integrated approach compared to a conventional laboratory approach. Your mission will be to characterize the...
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Fixed term contract
Post-doctorant en neuro-ingénierie et traitement du signal biomédical H/F
Cette extension de la technologie BCI soulève de nouveaux défis, comme la diminution ou la distorsion du contenu informatif du signal neuronal due à des lésions ou autres pathologies cérébrales, ou encore la modulation du signal neuronal liée à la rééducation du patient. [1] Benabid, A. L., Costecalde, T., Eliseyev, A., Charvet, G., Verney, A.,...
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Permanent contract
Engineer-Researcher in analytical chemistry
Title: Integration of an analytical protocol for the characterization of nanoparticles Our technological development project aims to develop a new concept for characterizing lipid nanoparticles (LNPs) that carry biomolecules. More specifically, the goal is to verify the analytical performance of an integrated approach compared to a conventional laboratory approach. Your mission will be to characterize the...
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