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phD
Multi-target capture strategy for micro total analysis systems
The concentration of biomarkers and pathogens in biological samples is generally limited by the preparation of these samples after their collection. In addition, their detection, when based on an antibody-antigen capture reaction, can be difficult to optimize within biosensors. If the approach which consists of functionalizing a wall to capture molecules or particles flowing in...
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phD
Wavefront shaping for photobiomodulation - Application to neurodegenerative diseases
Photobiomodulation consists in using light, in the visible/near infrared range, to treat or slow down the evolution of a pathology. In the case of Parkinson’s disease, a neurodegenerative disease without any curative treatment so far, the brain region responsible for symptoms is located in the midbrain area, deep in the brain, which requires neurosurgery to...
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phD
Conditional generative model for dose calculation in radiotherapy
Particle propagation through matter by Monte Carlo method (MC) is known for its accuracy but is sometimes limited in its applications due to its cost in computing resources and time. This limitation is all the more important for dose calculation in radiotherapy since a specific configuration for each patient must be simulated, which hinders its...
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phD
Design of a new light-sheet microscope for the temporal monitoring of organoids-on-chip
The subject of the thesis is the development of a fluorescence light-sheet microscope for the optical characterization of organoids-on-chips and 3D organoids. The thesis will focus on the conception of a compact multi-color 3D system, to allow time-lapse imaging of multi-scattering 3D samples directly in a cell culture incubator. The work will begin with a...
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phD
Hollow microneedle and capillary microfluidic system for InterStitial Fluide (ISF) monitoring
Interstitial fluid (ISF) is the fluid that occupies the space between blood capillaries and cells. ISF consists mainly of water, salts, sugars, hormones, neurotransmitters, CO2 and fatty acids. It is particularly interesting as it is described as a filtrate of plasma, but more accessible than blood for continuous monitoring. Continuous monitoring of ISF is targeted,...
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phD
Transcutaneous sampling of gaseous biomarkers
The development of wearable medical devices is a fundamental and essential in order to promote ambulatory medicine. Exhaled gases as transcutaneous gases (gases that diffuse through the skin) are known to carry molecules (quot;biomarkersquot;) representative of pathologies or degradation of the physiological state, the ambulatory monitoring of which would be a real diagnostic and monitoring...
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phD
Protection by self-decontaminating coatings against biocontamination of surfaces
The proposed PROBIO-ES project falls within the scope of the priority defense theme « biologie, santé, NRBC », and in particular the sub-themes of protection and decontamination. Its aim is to develop self-decontaminating surfaces for a number of terrestrial and space applications. The project has been shortlisted by CNES for the award of a 1/2...
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phD
Development of new antidote formulations based on chitosan-coated bilosome with active targeting, against intoxications by organophosphorus neurotoxins for nasal administration
The aim of this innovative project is to develop and validate the biological efficacy of new formulations including original and patented reactivators (CNRS/IRBA). These molecules present a large spectrum of action against acetylcholinesterase (AChE) inhibited by Organophosphorus Neurotoxins (NOPs), hence the interest in developing centrally effective antidotes for nose-to-brain administration. The novel bilosome-based formulations designed...
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phD
Multilayer encapsulation of cells by a centrifugation device
Cell encapsulation in bio-polymers is a rapidly expanding field in bioproduction, encompassing organoid or spheroid maturation, drug screening, cellular therapies, and bioengineering. This thesis contributes to these applications through the multilayer encapsulation of cells in bio-polymers with a wide viscosity range. The inner layer (core) provides a more favorable environment for the maturation and survival...